A new liquid biopsy test using artificial intelligence models could help spot a rare type of bone and soft tissue cancer that predominantly affects children and adolescents.
The test is being developed by researchers funded by British charity Cancer Research UK for Ewing sarcoma, a rare cancer with a high risk of spreading that can evade modern scanning techniques.
The blood test uses a machine learning model called EwingSign to identify patterns in DNA fragments rather than single mutations.
By reading these tumor “fingerprints,” it can distinguish cancer DNA from normal DNA.
In the study, the test detected signs of cancer in 15 of the 18 patients whose disease had already returned.
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