在英格蘭，國家安全指南建議使用環孢菌素，他克莫司和地爾硫卓，因為它們的治療窗口狹窄，並以商標名稱開具處方；對於他克莫司，則應減少器官移植排斥的機會。各種小型研究表明，對電子健康記錄（EHR）系統界面的更改可能會影響處方選擇。
這個研究評估EHR系統在製定有關環孢菌素，他克莫司和地爾硫卓的處方時是否違反安全指南，並進行用戶界面研究，以研究違反此類藥物的原因。
系統介面設計是不是真的會影響藥物的安全使用呢
In England, national safety guidance recommends that ciclosporin, tacrolimus, and diltiazem are prescribed by brand name due to their narrow therapeutic windows and, in the case of tacrolimus, to reduce the chance of organ transplantation rejection. Various small studies have shown that changes to electronic health record (EHR) system interfaces can affect prescribing choices.
Our objectives were to assess variation by EHR systems in breach of safety guidance around prescribing of ciclosporin, tacrolimus, and diltiazem, and to conduct user-interface research into the causes of such breaches.
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