Diagnostic tools for the identification of allergic versus non-allergic asthma are needed for new precision medicine-based treatments.
The researchers aim to detect specific IgE sensitization profiles in adult asthma patients from the LEAD cohort with micro-arrayed allergen molecules and to characterize IgE-sensitized and non-sensitized patients.
436 patients with current asthma were analyzed for IgE sensitizations to 110 micro-arrayed molecules from airborne and food allergen sources and by skin prick testing (SPT) with 10 allergen extracts.
IgE sensitization was detected in 73.2% of patients with asthma using 63 micro-arrayed respiratory allergens.
Micro-arrayed allergens allowed the identification of IgE reactivity profiles indicative of genuine sensitizations to different allergen sources.
Diagnosis based on allergen micro-arrays thus not only identifies precisely a subgroup of patients but may open the doors for personalized, allergen-specific forms of treatment for sensitized patients with asthma.
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