Stanford Medicine researchers have developed an artificial intelligence tool to help scientists better plan gene-editing experiments.
The technology, CRISPR-GPT, acts as a gene-editing "copilot" supported by AI to help researchers—even those unfamiliar with gene editing—generate designs, analyze data and troubleshoot design flaws.
CRISPR-GPT uses years of published data to hone the experimental design into something likely to be successful.
It can also predict off-target edits and their likelihood of causing damage, allowing experts to choose the best path forward.
The researcher showed an example that he typed his question into CRISPR-GPT's text box: "I plan to do a CRISPR activate in a culture of human lung cells, what method should I use?"
CRISPR-GPT responded like an experienced lab mate advising a new researcher. It drafted an experimental design, and at each step, explained its "thought" process, describing why the various steps were important.
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