NHS England will provide Microsoft 365 Copilot to 505,000 clinicians and support staff.
The deployment could reduce time spent on paperwork and allow more hours for direct patient care.
According to NHS England, the technology will streamline processes, improve capacity across Trusts and reduce costs.
Staff will use Copilot to create documents, analyse data and complete tasks faster.
The agreement follows a trial that took place in 2025.
According to the trial results, AI-powered support could save 43 minutes per staff member daily.
The findings showed that a full rollout could save up to 400,000 hours of staff time a month.
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